Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials / دانلود فایل

مشخصات کلی Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials

نویسنده کتاب (Author):

Rubin, Tamar; Clayton, Jacqueline; Adams, Denise; Persad, Rabin; Vohra, Sunita

انتشارات (Publisher):

BioMed Central Ltd. 2016-08-31

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Eosinophilic esophagitis, Outcome measures, Pediatric, Systematic review, Treatment      

توضیحات خلاصه (Summary):

Abstract Background Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic esophagitis (EoE) treatment trials. As secondary objectives, we compared trial disease definition to established concensus guidelines, and the efficacy of current EoE treatments. Methods We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL since 2001. We also searched clinical trial registries (portal.nihr.ac.uk; clinicaltrials.gov; isrctn.com; and anzctr.org.au) and references of included studies. We included RCTs of EoE treatment in patients 0–18 years. Two authors independently assessed articles. Results Eleven studies met inclusion criteria. All identified primary outcomes, however, of 9 unique primary outcomes, only 2 were used in more than one study. In total, 25 unique primary and secondary outcome measures were employed for pediatric EoE treatment trials. Measurement properties and rationale for their selection was rarely provided. Uptake of consensus-based diagnostic criteria was 25 % in trials initiated after 2011. Due to the small number and heterogeneity of studies obtained, no meta-analysis of treatment efficacy could be undertaken. This SR was limited to exclusively pediatric RCTs. Conclusions The results of this study confirm the need for a standardized set of core outcomes that are universally reported in pediatric EoE trials. Consistent disease definition and standardized outcome reporting will facilitate meta-analyses across similar trials and inform future clinical decision-making. Systematic review registration number CRD42013003798  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Rubin, Tamar; Clayton, Jacqueline; Adams, Denise; Persad, Rabin; Vohra, Sunita

شناسه OCLC:979265195

Language Note:English

Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population / دانلود فایل

مشخصات کلی Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population

نویسنده کتاب (Author):

Cubero, José; Isidoro-García, María; Segura, Nieves; Benito Pescador, David; Sanz, Catalina; Lorente, Félix; Dávila, Ignacio; Colás, Carlos

انتشارات (Publisher):

BioMed Central Ltd. 2016-07-26

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Filaggrin, FLG, R501X, 2282del4, Asthma, SNPs, Atopy      

توضیحات خلاصه (Summary):

Abstract Background Several null-mutations in the FLG gene that produce a decrease or absence of filaggrin in the skin and predispose to atopic dermatitis and ichthyosis vulgaris have been described. The relationship with asthma is less clear and may be due to the influence of atopy in patients with associated asthma. Methods Four hundred individuals were included, 300 patients diagnosed with asthma divided into two groups according to their phenotype (allergic and non-allergic asthma) and 100 strictly characterized controls. The coding region and flanking regions of the FLG gene were amplified by PCR. We proceeded to the characterization of potential gene variants in that region by RFLP and sequencing and analysed their association with lung function parameters, asthma control and severity, and quality of life. Results We identified two null-mutations (R501X and 2282del4), seven SNPs previously described in databases and three SNPs that had not been previously described. One of the SNP identified in this study (1741A > T) was more frequently detected in patients with non-allergic asthma, worse FVC, FEV1 and PEF values and a higher treatment step. In addition, lowered spirometric values were observed in the non-allergic group carrying any of the nonsynonymous SNPs. Conclusions In the association study of genetic variants of the FLG gene in our population the 1741A > T polymorphism seems to be associated with non-allergic asthma.  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Cubero, José; Isidoro-García, María; Segura, Nieves; Benito Pescador, David; Sanz, Catalina; Lorente, Félix; Dávila, Ignacio; Colás, Carlos

شناسه OCLC:979265193

Language Note:English

Prevalence and clinical features of adverse food reactions in Portuguese adults / دانلود فایل

مشخصات کلی Prevalence and clinical features of adverse food reactions in Portuguese adults

نویسنده کتاب (Author):

Lozoya-Ibáñez, Carlos; Morgado-Nunes, Sara; Rodrigues, Alexandra; Lobo, Cláudia; Taborda-Barata, Luis

انتشارات (Publisher):

BioMed Central Ltd. 2016-08-05

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Adverse food reaction, Food allergy, Adults, Prevalence, Cutaneous tests, Open food challenge      

توضیحات خلاصه (Summary):

Abstract Background Only one previous study, via telephone call, on the prevalence of self-reported food allergies has been performed in Portugal, in a small sample of adults. The objective of this study was to determine the prevalence of self-reported and probable food allergy, analyze the clinical features and involved foods in Portuguese adults. Methods Population-based, cross-sectional study performed in various healthcare centres from central Portugal. All 1436 randomly selected individuals (median age: 45 years, 50.6 % female) replied to a validated food allergy questionnaire by phone. Those who reported an adverse food reaction were invited to come to the hospital, where clinical history was taken, skin prick (SPT) and prick-prick skin (SPPT) tests were performed and food allergen-specific IgE levels (sIgE) were determined. An open oral challenge was performed in selected cases. Cases of positive clinical history of immediate (up to 2 h after ingestion) reaction in association with positive food sIgE levels and/or skin prick tests were classified as IgE-associated probable food allergy. Cases of positive clinical history of delayed (more than 2 h after ingestion) and negative food sIgE levels independently of positive SPT or SPPT results were classified as non-IgE associated probable food allergy. Results The prevalence of probable food allergy in our sample was 1 %, with shellfish and fish as the most frequently implicated foods. IgE-mediated probable food allergy occurred in 0.71 % of cases, with shellfish, peanut and nuts mainly involved. Cutaneous symptoms were most frequently reported. Prevalence values and food types were discrepant between self-reported and probable food allergies. Conclusions The prevalence of probable food allergies in Portuguese adults is low, is mostly related to shellfish, peanut and nuts and most frequently involves cutaneous symptoms.  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Lozoya-Ibáñez, Carlos; Morgado-Nunes, Sara; Rodrigues, Alexandra; Lobo, Cláudia; Taborda-Barata, Luis

شناسه OCLC:979265192

Language Note:English

Analysis of feline and canine allergen components in patients sensitized to pets / دانلود فایل

مشخصات کلی Analysis of feline and canine allergen components in patients sensitized to pets

نویسنده کتاب (Author):

Ukleja-Sokołowska, Natalia; Gawrońska-Ukleja, Ewa; Żbikowska-Gotz, Magdalena; Socha, Ewa; Lis, Kinga; Sokołowski, Łukasz; Kuźmiński, Andrzej; Bartuzi, Zbigniew

انتشارات (Publisher):

BioMed Central Ltd. 2016-11-30

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Cat, Dog, IgE, Allergen components, Fel d 1, Lipocalin, Albumin      

توضیحات خلاصه (Summary):

Abstract Background Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insight into the evolution of a given patients sensitizations, and allows for a more precise evaluation of their prognoses. Methods 70 patients (42 women and 28 men, aged 18–65, with the average of 35.5) with a positive feline or canine allergy diagnosis were included in the research group. 30 patients with a negative allergy diagnosis were included in the control group. The total IgE levels of all patients with allergies as well as their allergen-specific IgE to feline and canine allergens were measured. Specific IgE levels to canine (Can f 1, Can f 2, Can f 3, Can f 5) and feline (Fel d 1, Fel d 2, Fel d 4) allergen components were also measured with the use of the ImmunoCap method. Results Monosensitization for only one canine or feline component was found in 30% of patients. As predicted, the main feline allergen was Fel d 1, which sensitized as many as 93.9% of patients sensitized to felines. Among 65 patients sensitized to at least one feline component, for 30 patients (46.2%) the only sensitizing feline component was Fel d 1. Only 19 patients in that group (63.3%) were not simultaneously sensitized to dogs and 11 (36.7%), the isolated sensitization to feline Fel d 1 notwithstanding, displayed concurrent sensitizations to one of the canine allergen components. Fel d 4 sensitized 49.2% of the research group.64.3% of patients sensitized to canine components had heightened levels of specific IgE to Can f 1. Monosensitization in that group occurred for 32.1% of the patients. Sensitization to Can f 5 was observed among 52.4% of the patients. Conclusions Concurrent sensitizations to a few allergic components, not only cross-reactive but also originating in different protein families, are a significant problem for patients sensitized to animals.  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Ukleja-Sokołowska, Natalia; Gawrońska-Ukleja, Ewa; Żbikowska-Gotz, Magdalena; Socha, Ewa; Lis, Kinga; Sokołowski, Łukasz; Kuźmiński, Andrzej; Bartuzi, Zbigniew

شناسه OCLC:979265180

Language Note:English

Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma / دانلود فایل

مشخصات کلی Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

نویسنده کتاب (Author):

Caswell-Smith, Rachel; Cripps, Terrianne; Charles, Thom; Hosking, Alexander; Handigol, Meghana; Holweg, Cecile; Matthews, John; Holliday, Mark; Maillot, Corentin; Fingleton, James; Weatherall, Mark; Beasley, Richard; Braithwaite, Irene; On behalf of the Periostin Study Team

انتشارات (Publisher):

BioMed Central Ltd. 2017-02-08

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Asthma, Biomarker, Daytime variation, Periostin      

توضیحات خلاصه (Summary):

Abstract Background We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma. Methods Serum periostin was measured at 2-h intervals from 0800 to 1800 h in 16 adult participants with stable asthma prescribed inhaled corticosteroid and long-acting beta-agonist therapy, and in 16 otherwise healthy participants without asthma. Mixed linear models were used to compare time zero (08:00 h) with subsequent measurement time for serum periostin for both groups. Results In both asthma and non-asthma, the mean (SD) serum periostin levels continuously reduced during the day from 53.5 (13.6) ng/mL at 0800 h to 50.9 (13.4) ng/mL at 1800 h (difference log periostin −0.05, P ≤ 0.001) and 50.5 (13.0) ng/mL at 0800 h to 46.2 (11.5) ng/mL at 1800 h (difference log periostin −0.08, P ≤ 0.001) respectively. Conclusions Periostin values are higher in the morning compared with the afternoon in asthmatic and non-asthmatic adults. The small magnitude of the variation in serum periostin levels suggests that the time of day in which the serum periostin measurements are made is unlikely to influence treatment decisions if a specific serum periostin level is used to predict treatment responsiveness. Trial registration Australia New Zealand Trials Registry (ACTRN12614000072617)  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Caswell-Smith, Rachel; Cripps, Terrianne; Charles, Thom; Hosking, Alexander; Handigol, Meghana; Holweg, Cecile; Matthews, John; Holliday, Mark; Maillot, Corentin; Fingleton, James; Weatherall, Mark; Beasley, Richard; Braithwaite, Irene; On behalf of the Periostin Study Team

شناسه OCLC:979265176

Language Note:English

High rate of house dust mite sensitization in a shrimp allergic southern Ontario population / دانلود فایل

مشخصات کلی High rate of house dust mite sensitization in a shrimp allergic southern Ontario population

نویسنده کتاب (Author):

Rosenfield, Lana; Tsoulis, Michael; Milio, Kirolos; Schnittke, Meghan; Kim, Harold

انتشارات (Publisher):

BioMed Central Ltd. 2017-01-19

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

House dust mite, Shrimp, Tropomyosin, Canadian, Allergen cross-reactivity, Food allergy, Skin test      

توضیحات خلاصه (Summary):

Abstract Background Shrimp and house dust mite (HDM) allergies are common in Canadians. Often, both of these allergies occur in the same patient. This may be due to homology of tropomyosin or other potentially shared proteins. The aim of our study was to assess the frequency of house dust mite sensitization in a shrimp allergic Canadian population. Methods We undertook a retrospective chart review of shrimp allergic patients at an outpatient allergy clinic in Kitchener, Ontario, Canada. Our primary endpoint was to assess for presence of HDM sensitization in this population. Patients were categorized into approximate quartiles. We assessed the severity of the shrimp reactions, correlated shrimp skin test size to HDM skin test size, and measured the proportion of patients with atopic symptoms. Results We identified 95 shrimp allergic patients who were tested for house dust mite. 86 (90.5%) of these patients had a positive skin test to HDM. Patients with a shrimp skin test ≥5 mm were 5.31 times (95% CI, 1.55–18.14; p = 0.008) more likely to exhibit a dust mite skin test ≥5 mm than patients with a shrimp skin test <5 mm. The odds of a patient with a shrimp skin test between 10 and 18 mm having a larger HDM skin test were 3.93 times (95% CI 1.03–14.98, p = 0.045) the odds for a patient with a shrimp skin test size between 3 and 4 mm. We did not find a correlation between shrimp skin test size and shrimp reaction symptom grade (p = 0.301). Conclusion In our Canadian patients, we found a large majority of shrimp allergic patients to be sensitized to HDM. We found that patients with a large skin test to shrimp were more likely to have a large skin test to HDM compared to those patients with a small skin test to shrimp. We did not find a correlation between shrimp skin test size and shrimp reaction symptom severity. Most of these patients had symptoms of rhinitis and/or asthma that may have been caused by house dust mite allergy.  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Rosenfield, Lana; Tsoulis, Michael; Milio, Kirolos; Schnittke, Meghan; Kim, Harold

شناسه OCLC:979265174

Language Note:English

Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy / دانلود فایل

مشخصات کلی Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy

نویسنده کتاب (Author):

Ling, Ling; Ospina, Maria; Sideri, Kyriaki; Vliagoftis, Harissios

انتشارات (Publisher):

BioMed Central Ltd. 2016-07-25

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Adult, Food allergy, Skin prick test, Specific IgE, Agreement      

توضیحات خلاصه (Summary):

Abstract Background Food allergy is a common clinical problem in adults. Given logistical barriers to conducting food challenges, the use of skin prick test (SPT) and specific IgE (sIgE) are important in establishing the diagnosis. The purpose of this study is to investigate the agreement of SPT and sIgE results in adults presenting to an allergy clinic with suspected food allergy. Methods Retrospective analysis of medical records at the University of Alberta Allergy Clinic between September 2013 and May 2015 was performed. Demographic, medical history as well as SPT and specific IgE results were recorded. Agreement of SPT and sIgE for individual food allergens was analyzed by Kappa statistics. Results Data from 260 patients was collected. The population was predominantly female, often having other atopic diseases. Very few food challenges were performed; IgE mediated food allergy was diagnosed in a minority (29.6 %) of cases. Kappa values which reached statistical significance were moderate for peanut ĸ = 0.535 (p = 0.0002, CI 0.364–0.707), walnut ĸ = 0.408 (p = 0.001 CI 0.159–0.657), pecan ĸ = 0.530 (p = 0.001 CI 0.211–0.848), and lobster ĸ = 0.543 (p = 0.004 CI 0.197–0.889), substantial for pistachio ĸ = 0.657 (p = 0.023 CI 0.224–1.000), codfish ĸ = 0.770 (p = 0.0002 CI 0.558–0.983), shrimp ĸ = 0.627 (p = 0.0006 CI 0.383–0.871) and egg white ĸ = 0.625 (p = 0.002 CI 0.293–0.957), almost perfect for cashew ĸ = 0.894 (p = 0.0008 CI 0.693–1.000) and salmon ĸ = 0.874 (p = 0.004 CI 0.705–1.000). Conclusions The agreement between SPT and sIgE results on adults being evaluated for food allergy is at least moderate or better for peanut, walnut, pecan, pistachio, cashew, lobster, shrimp, codfish, salmon and egg white. This should be reassuring for patients who have contraindications or restricted access to either test as the results for the above allergens will likely agree. These findings may suggest that these tests could possibly be interchangeable in adults being evalu  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Ling, Ling; Ospina, Maria; Sideri, Kyriaki; Vliagoftis, Harissios

شناسه OCLC:979265169

Language Note:English