ژورنال اصلی BioMed Central Ltd.

download pdf Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy, دانلود Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy,Ling, Ling; Ospina, Maria; Sideri, Kyriaki; Vliagoftis, Harissios, کتاب های Ling, Ling; Ospina, Maria; Sideri, Kyriaki; Vliagoftis, Harissios,BioMed Central Ltd. 2016-07-25, لیست کتاب های BioMed Central Ltd. 2016-07-25,WorldCat, کتاب های WorldCat

گت بلاگز Internet Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials / دانلود فایل

مشخصات کلی Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials

نویسنده کتاب (Author):

Rubin, Tamar; Clayton, Jacqueline; Adams, Denise; Persad, Rabin; Vohra, Sunita

انتشارات (Publisher):

BioMed Central Ltd. 2016-08-31

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Eosinophilic esophagitis, Outcome measures, Pediatric, Systematic review, Treatment      

توضیحات خلاصه (Summary):

Abstract Background Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic esophagitis (EoE) treatment trials. As secondary objectives, we compared trial disease definition to established concensus guidelines, and the efficacy of current EoE treatments. Methods We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL since 2001. We also searched clinical trial registries (portal.nihr.ac.uk; clinicaltrials.gov; isrctn.com; and anzctr.org.au) and references of included studies. We included RCTs of EoE treatment in patients 0–18 years. Two authors independently assessed articles. Results Eleven studies met inclusion criteria. All identified primary outcomes, however, of 9 unique primary outcomes, only 2 were used in more than one study. In total, 25 unique primary and secondary outcome measures were employed for pediatric EoE treatment trials. Measurement properties and rationale for their selection was rarely provided. Uptake of consensus-based diagnostic criteria was 25 % in trials initiated after 2011. Due to the small number and heterogeneity of studies obtained, no meta-analysis of treatment efficacy could be undertaken. This SR was limited to exclusively pediatric RCTs. Conclusions The results of this study confirm the need for a standardized set of core outcomes that are universally reported in pediatric EoE trials. Consistent disease definition and standardized outcome reporting will facilitate meta-analyses across similar trials and inform future clinical decision-making. Systematic review registration number CRD42013003798  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Rubin, Tamar; Clayton, Jacqueline; Adams, Denise; Persad, Rabin; Vohra, Sunita

شناسه OCLC:979265195

Language Note:English

نویسنده : getblogs